According to Official Guinness Records,
The oldest cardinal ever was Giorgio da Costa (Portugal) who was born in 1406 and died in Rome, Italy on 18 September 1508 aged 102. Created a cardinal in 1476, he was also Archbishop of Lisbon and is buried at Santa Maria del Popolo, Rome, Italy.
For a complete list of 1508 records, please visit 1508 Guinness Records in Italy.